Generated by All in One SEO v4.9.5.1, this is an llms.txt file, used by LLMs to index the site. # billmiller ## Sitemaps - [XML Sitemap](https://williammillermd.com/sitemap.xml): Contains all public & indexable URLs for this website. ## Posts - [Part 3: Epigenetics And Cancer | Epigenetic Modification](https://williammillermd.com/part-3-epigenetics-and-cancer-epigenetic-modification/) - New research is demonstrating that the etiology of cancer is complex. Epigenetic modifications of the genomes of cancer cells appear to be quite important. These are changes that do not necessarily reflect the exact DNA sequences within a cell, but alter, by various means, the expression of the underlying code. It is increasingly apparent that epigenetic modification may - [The Hygiene Hypothesis, How Our Overprotective Nature Is One Of The Leading Causes Of Allergies](https://williammillermd.com/the-hygiene-hypothesis-how-our-overprotective-nature-is-one-of-the-leading-causes-of-allergies/) - I was young once. Now, I am a boomer. When I was growing up, I never knew any child with a food allergy. Allergies of any kind seemed rare. Yet now, allergic concerns are frequently encountered? Just a few weeks ago, I was on a flight from Phoenix to Philadelphia. Shortly after the flight began, - [Global Epidemics – The Ebola Outbreak And The Reprecussions Of Infectious Diseases On A World Wide Scale](https://williammillermd.com/global-epidemics-the-ebola-outbreak-and-the-reprecussions-of-infectious-diseases-on-a-world-wide-scale/) - The agitating Ebola outbreak has captured headlines. There are some who undoubtedly assume that this kind of epidemic is unusual. However, epidemic disease has always been a part of our biological system. Pandemics or the form of infectious disease that can spread across a continent or even the entire world are ancient processes too. As the Ebola - [Outbreak Of Ebola Will Not Be The Last Global Epidemic, Time To Hit The Reset Button On How We Treat It](https://williammillermd.com/outbreak-of-ebola-will-not-be-the-last-global-epidemic-time-to-hit-the-reset-button-on-how-we-treat-it/) - The outbreak of Ebola will not be the last global epidemic. I recently was interviewed by Jeanine Prezioso of Reuters concerning this subject. The original article appeared here — http://blogs.reuters.com/global-markets-forum/2014/10/23/ebola-will-not-be-the-last-global-epidemic-time-to-hit-the-reset-button-on-how-we-treat-it-physician/. —- Ebola will not be the last global epidemic. It is, however, the first to spread as we hop on planes, rely on oil and - [The Expanded Role Of Viruses In Human Health](https://williammillermd.com/the-expanded-role-of-viruses-in-human-health/) - Our traditional view of viruses has been narrowly perceived to that their sole role is as organic aggressors. Certainly, their visible effect upon our human history, at least until now, has only been understood as the source of myriad scourges throughout human history. Viral epidemics have accounted for an enormous number of deaths including measles, - [Are You Smarter Than A Reptile](https://williammillermd.com/are-you-smarter-than-a-reptile/) - Are You Smarter Than a Reptile? William B. Miller, Jr. M.D. Are you smarter than a reptile? In many respects, you certainly are. After all, no reptile is going to read this article. However, our clearly superior intellectual abilities for certain skills has seduced us towards a dismissive attitude towards the surprisingly deep and broad range - [Extinctions And Pathogenesis](https://williammillermd.com/extinctions-and-pathogenesis/) - A recent article in LiveScience proclaims that ‘Microbes may have caused Earth’s biggest extinction’. The findings are part of a new study in the Proceedings of the National Academy of Science, ‘Methanogenic burst in the end-Permian carbon cycle’. The authors believe that there was a rapid burst of microbial activity triggered by massive volcanism in the end-Permian period that released enormous - [‘Termite’ Robots Illuminate Cellular Engineering](https://williammillermd.com/termite-robots-illuminate-cellular-engineering/) - Insight into biologic processes can sometimes be gleaned from unexpected sources. Harvard University researchers have designed and programmed a group of tiny robots to mimic the basic building strategies of termites. The robots are equipped with sensors and can assess their surroundings and collaborate through an innovative technique modeled on swarm intelligence. Lee Hotz in - [Spread Of Infectious Disease A Consequence Of Climate Change](https://williammillermd.com/spread-of-infectious-disease-a-consequence-of-climate-change/) - The single most pressing consequence of climate change, whether global or localized, will be in the shifting patterns and spread of infectious disease. Substantial alterations in temperature and humidity can directly relate to the distribution and virulence of many microbial pathogens, no matter the underlying cause. This correlates with the rich complexity and diversity of all - [The Quintessential Work Of Charles Darwin, On The Origin Of Species, Wasn’t First Among Evolutionary Theories](https://williammillermd.com/the-quintessential-work-of-charles-darwin-on-the-origin-of-species-wasnt-first-among-evolutionary-theories/) - When most individuals think about evolutionary theories, Charles Darwin’s On the Origin of Species often comes first to mind. His insightful analysis of evolution through natural selection and descent by gradual modification has dominated our debate since his publication of On the Origin of Species in 1859. However, multiple alternatives continue to be debated and there were theories of evolution - [Mass Extinction Events Diffrentiate Patrick Mathews’ Work from Darwin Evolution Theory](https://williammillermd.com/mass-extinction-events-diffrentiate-patrick-mathews-work-from-darwin-evolution-theory/) - The publication of Charles Darwin evolution theory found in Origin of Species in 1859 and the Descent of Man in 1871 initiated a clamorous public and scientific debate that remains unabated today. His insightful analysis of the means of evolution by natural selection and descent by gradual modification has undergirded the discussion and investigation ever since.Interestingly, Darwin was not - [Cognition-Based Evolution: A Modern Theory Of Genetic Evolution](https://williammillermd.com/cognition-based-evolution-a-modern-theory-of-genetic-evolution/) - Cognition-Based Evolution is a modern theory of evolution that is entirely centered within the context of all organisms as hologenomic beings. In viewing the cell as the basic agency of evolutionary change and viewing natural selection as a filter instead of a driving force, it stands apart from Neo-Darwinism. What are the major tenets? Evolutionary - [Neo-Darwinism And Modern Evolutionary Synthesis](https://williammillermd.com/neo-darwinism-and-modern-evolutionary-synthesis/) - It is not well recognized that Darwin in his book On the Origin of Species did not specifically explain how a species originates but discussed how an organism became fitter and better adapted gradually over time. Even during his lifetime, others pointed out the problem of dilution of favorable traits by blending within the reproductive population. George - [Microbiomes And Their Role In Evolutionary Biology](https://williammillermd.com/microbiomes-and-their-role-in-evolutionary-biology/) - There are currently estimated to be at least 100 trillion microbes that are in and on us — bacteria, viruses, fungi and others. They outnumber our innate cells by a factor of 10 to 1 or more. We cannot do without many of them for proper function of our brains, gut, central nervous and immune - [Books On Evolution](https://williammillermd.com/books-on-evolution/) - It is surprising how few people have actually ever read Darwin’s On the Origin of Species by the Means of Natural Selection (1859) since it is referenced abundantly and considered a foundational event in evolutionary biology. It is not surprising then that it is generally unappreciated that Darwin did not actually answer the specific question of exactly - [Metagenomic Assembly](https://williammillermd.com/metagenomic-assembly/) - Metagenomic evaluation of any environment, ecology or tissue sample requires extensive computational power in order to properly assess large volumes of sequence data. This is required to mobilize an accurate representation of genetic diversity in a sample. New techniques in de novo metagenomic assembly effectively filter the total amount of data to be analyzed; yet, vast - [Part 1: Definition Of Epigenetics And Acquired Characteristics](https://williammillermd.com/part-1-definition-of-epigenetics-and-acquired-characteristics/) - This is the first of a five part series discussing epigenetics. In science, what is old can once again become the new. To better understand the definition of epigenetics, we must look back at the time before Darwin. Charles Darwin proposed his version of natural selection and heritable descent by gradual modification in 1859, but before that, - [Part 2: Epigenetics And Evolution – Transgenerational Epigenetic Inheritance](https://williammillermd.com/part-2-epigenetics-and-evolution-transgenerational-epigenetic-inheritance/) - New scientific findings involving epigenetics are having a profound impact on our understanding of evolutionary mechanisms. It is becoming increasingly apparent that epigenetic modifications play a critical role in the regulation of gene expression. In so doing, they produce phenotypic changes. It is becoming abundantly clear that these influences are an important factor in our own - [Part 4: Epigenetics And Chromatin – Epigenetic Changes](https://williammillermd.com/part-4-epigenetics-and-chromatin-epigenetic-changes/) - Chromatin represents the combination of both the DNA and proteins in a cell nucleus. This combined material can assume specific configurations. This chromatin architecture is currently viewed as having a critical role in controlling gene expression and DNA replication. The primary protein elements of chromatin, or histones, compact DNA and assist in mitosis. Epigenetic changes - [Part 5: Epigenetics & Homosexuality](https://williammillermd.com/part-5-epigenetics-homosexuality/) - It is now well established that same sex attraction is not volitional. In The Microcosm Within, the incompatibility of any adequate theory for the persistence of homosexuality within the standard Darwinian construct of natural selection is fully discussed. The evidence points to same sex attraction as a genetic event representing the conservation of an original cellular - [Viral Metagenomic Studies](https://williammillermd.com/viral-metagenomic-studies/) - Viral genomics is the study of the full composition of viral genetic source material in the environment. Studies utilizing new technologies are identifying an enormous range of viral diversity that is typically invisible to standard studies. The hologenomic participants in an ecology cannot be fully understood unless these entities are identified. The metagenomic approach has improved our understanding - [Natural Selection Theory And Same Sex Attraction](https://williammillermd.com/natural-selection-theory-and-same-sex-attraction/) - Darwinism has always been bedeviled by same sex attraction. Evidence indicates that this trait is genetically rooted. Yet, if same sex attraction remains eternally common, how can it still resist being expunged by natural selection? Few traits can be regarded as more likely to govern reproductive frequency than same sex attraction. However, it is certainly - [Biological Complexity: A Result Of Cognition-Based Evolution](https://williammillermd.com/biological-complexity-a-result-of-cognition-based-evolution/) - What produces biological complexity, novelty or impels the origin of species? When examined through all available contemporary evidence, the expression of novel phenotype and metabolic function emerges from processes other than natural selection and fitness as they have been traditionally assessed. To best understand this issue, it is useful to closely consider a facet that - [Why Is Natural Selection Important? It’s Role In Evolutionary Development](https://williammillermd.com/why-is-natural-selection-important-its-role-in-evolutionary-development/) - I had recently been asked to comment on a dialogue between two evolutionary biologists as they debated the role of natural selection in evolution. Both assumed that that there was no valid alternative. Neither seemed to grasp that there are actually are two differing conditions in which its influence might be fully evaluated. Any assessment of the ## Pages - [Home](https://williammillermd.com/) - Senior Fellow (Bioverse Foundation), Evolutionary Biologist, Medical Doctor, Scientific Advisor, Science Writer, Author And Co-Author Of Seven Science Books And Dozens Of Peer-Reviewed Academic Publications. - [Interviews](https://williammillermd.com/interviews/) - 3/1/17: Radio interview with KSCJ in Sioux Falls, IA 2/27/17: Radio interview with WSVA in Harrisonburg, VA 2/24/17: Radio interview with KDKA in Pittsburgh, PA 2/24/17: Magazine interview with Hospital Infection Control & Prevention (Atlanta, GA) 2/23/17: Radio interview with WILS in Lansing, MI 2/23/17: Radio interview with WVON in Chicago, IL 11/6/16: Radio Interview with WBSD in Burlington, WI 10/21/16: Radio interview with Voice - [Articles](https://williammillermd.com/articles/) - Media - Dr. William B. Miller Jr - Phoenix, AZ - [About Dr. Miller](https://williammillermd.com/about-dr-miller/) - My expertise in the microbiome and extensive medical training have led to a novel and academically sound approach to evolutionary development which also has broad implications for medical research and personal health. - [Bioverse Foundation](https://williammillermd.com/bioverse-foundation/) - Bioverse Foundation - - Dr. William B. Miller Jr - Phoenix, AZ - [Bill Miller Jr.](https://williammillermd.com/bill-miller-jr/) - Resume - Dr. William B. Miller Jr - Phoenix, AZ - [Contact Dr. Miller](https://williammillermd.com/contact-us/) - Contact Dr. Miller - Dr. William B. 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Miller Jr - Phoenix, AZ - [The Microcosm Within: Evolution and Extinction in the Hologenome](https://williammillermd.com/the-microcosm-within/) - The Microcosm Within takes its readers on a sweeping scientific journey that reorganizes our thinking about our biological selves, evolution, and extinction. The Microcosm Within illuminates how immunological factors dominate evolution and extinction. - [Bioverse: How The Cellular World Contains The Secrets to Life's Biggest Questions](https://williammillermd.com/bill-miller-bioverse/) - For as long as humans have been on Earth, we have looked up to the stars for clues to our own existence. Medical doctor and evolutionary biologist William B. Miller, Jr. suggests that we may find more meaningful solutions at the end of a microscope rather than a telescope. Using powerful analogies and exacting science, - [The Microcosm Within: Evolution and Extinction in the Hologenome](https://williammillermd.com/bill-miller-microcosm/) - The Microcosm Within: Evolution and Extinction in the Hologenome You are not what you think you are. New research is transforming how we understand ourselves—from a singular ‘self’ to a vast cooperative, co-dependent and collaborative network of cellular environments and ecologies—a microcosm within. From this unique perspective, a startling revision of evolutionary theory unfurls. Sharply - [Privacy Policy](https://williammillermd.com/privacy-policy-2/) - Your privacy is very important to us. Accordingly, we have developed this Policy in order for you to understand how we collect, use, communicate and disclose and make use of personal information. The following outlines our privacy policy. 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